HELPING PATIENTS
BREATHE EASIER

ABOUT

At Aiolos Bio, we are dedicated to revolutionizing the treatment landscape for respiratory disease and other immune conditions. We’re on a mission to reimagine therapies that bring hope and relief to patients and caregivers alike.

Aiolos Bio is an accomplished team of seasoned drug developers with decades of industry experience and operational leadership. With over 30 FDA approvals, we’ve successfully developed and launched products for a range of immune conditions, including asthma, rheumatoid arthritis, IPF, and more.

Our vision is embodied in our current focus – the development of a groundbreaking anti-TSLP asset. This asset boasts the potential of impressive efficacy and a dramatically less frequent dosing schedule compared to current standard of care. Our ultimate goal is to provide patients and caregivers with more efficacious therapies that significantly reduce treatment burden.

TEAM

Leadership

Khurem Farooq

Khurem Farooq

Co-Founder and Chief Executive Officer

Jane Hughes, PhD

Jane Hughes, PhD

Chief Scientific Officer

Ashley Taylor

Ashley Taylor

Chief Technical Officer

Chris Clevenger, PhD

Chris Clevenger, PhD

SVP, Clinical Operations

Michael Doherty, BSc

Michael Doherty

Head, Regulatory Strategy

Kim Harrow

Kim Harrow

VP, Life Cycle Management

Elizabeth Holt, MBA

Elizabeth Holt

VP, Corporate Strategy and Operations

Peter MacBride

Peter MacBride

VP, Commercial Strategy and Operations

Andrew Prosser

Andrew Prosser

SVP, Finance

Board of Directors

John F Milligan, Ph.D.

John F. Milligan, PhD

Chairman of the Board

Tony Adamis, MD

Tony Adamis, MD

Co-Founder and Board Member

Khurem Farooq

Khurem Farooq

Co-Founder and Chief Executive Officer

Michael Gladstone

Michael Gladstone

Partner, Atlas Venture

Wouter Joustra

Wouter Joustra

General Partner, Forbion

Maha Katabi, PhD

Maha Katabi, PhD

General Partner, Sofinnova Investments

Amir Zamani, MD

Amir Zamani, MD

Managing Director, Bain Capital Life Sciences

Investors

Atlas Venture
Bain Capital
Forbion
RA Capital
Sofinnova Investments
Atlas Venture
Bain Capital
Forbion
RA Capital
Sofinnova Investments

OUR FIRST ASSET:
AIO-001

AIO-001 is a monoclonal antibody which specifically targets and blocks TSLP, a validated driver of inflammation in diseases like asthma. TSLP inhibition is the only biological approach that has demonstrated clinical benefit for patients with all forms of moderate-to-severe asthma.

AIO-001 has demonstrated high potency and an extended half-life in pre-clinical studies and initial clinical trials. AIO-001’s unique properties allow investigation in clinical trials as a therapy that only needs to be administered every six months. With the convenience of biannual dosing, patients can focus less on managing asthma and more on living life to the fullest, reducing the impact of asthma on their daily lives.

ABOUT MODERATE-TO-SEVERE ASTHMA

Asthma presents a significant and growing global health challenge, impacting more than 260 million individuals worldwide and contributing to over 450,000 annual deaths.1 In the United States, this respiratory condition affects a staggering 25 million people, nearly 8% of the total population.2 Despite the use of inhaled corticosteroids (ICS), a significant proportion of individuals continue to grapple with uncontrolled asthma symptoms. Notably, a subset of patients, approximately 5%-10%, falls under the category of severe asthma,3-6 which remains uncontrolled even with optimized high-dose ICS treatment or worsens when high-dose treatment is reduced.

References
  1. Global Burden of Disease Study 2019, The Lancet. 2020;396(10258):1204-22. 
  2. CDC National Center for Health Statistics, National Health Interview Survey (NHIS). National Surveillance of Asthma: United States, 2001–2021.
  3. Rönnebjerg L, Axelsson M, Kankaanranta H, Backman H, Rådinger M, Lundbäck B, Ekerljung L. Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics. J Asthma Allergy. 2021 Sep 16;14:1105-1115. Doi: 10.2147/JAA.S327659. PMID: 34556999; PMCID: PMC8454418. 
  4. Backman H, Jansson SA, Stridsman C, Eriksson B, Hedman L, Eklund BM, Sandström T, Lindberg A, Lundbäck B, Rönmark E. Severe asthma-A population study perspective. Clin Exp Allergy. 2019 Jun;49(6):819-828. Doi: 10.1111/cea.13378. PMID: 30817038.
  5. Von Bulow A, Kriegbaum M, Backer V, Porsbjerg C. The prevalence of severe asthma and low asthma control among Danish adults. J Allergy Clin Immunol Pract. 2014;2(6):759–767. Doi: 10.1016/j.jaip.2014.05.005.
  6. Hekking PW, Wener RR, Amelink M, Zwinderman AH, Bouvy ML, Bel EH. The prevalence of severe refractory asthma. J Allergy Clin Immunol. 2015;135(4):896–902. Doi: 10.1016/j.jaci.2014.08.042.

CONTACT

Do you have questions or want to learn more about our transformative work? Reach out to us using the form here. We value your input and are excited to engage with like-minded individuals, potential partners, and collaborators who share our passion for innovation in respiratory and inflammatory disease research.

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